The Los Angeles Business Journal’s index of the 200 largest local public companies closed down for the week ended Oct. 23 as the markets reacted to mixed third quarter financial reports.

The LABJ index closed down 2 percent to 108.55, with decliners outpacing gainers 121 to 60.

Los Angeles real estate investment trust Maguire Properties Inc. fell 22 percent to $2.31 after an analyst’s downgrade. Downtown’s largest office landlord has been struggling under high debt, defaulting on some loans and losing control of several properties.

DineEquity Inc., the Glendale parent of IHOP and Applebee’s, fell 17 percent to $21.73, and Los Angeles chain California Pizza Kitchen Inc. lost 14 percent to $13.61 on concerns about the poor economy’s impact on the casual dining sector.

Among top gainers was Joe’s Jeans Inc., a premium jeans maker based in Commerce, which soared 84 percent to $1.47 after reporting strong quarterly earnings. Manhattan Beach shoe maker Skechers USA Inc. gained 14 percent to $24.44 after reporting lower, but still better-than-expected earnings.